Well no one responded to my email about if the DLS-45 is isolated from the output, but in the mean time, I did find a statement on their website saying that the output can be hooked in parallel or series with more of their chargers to get more voltage or amperage output. So it should be safe to say that the DLS-45’s output is isolated from the input. I am planning on using this for my accessory battery charger since it will work from the 144vDC pack and 120vAC.